The intrinsic helix-forming tendency of L-alanine.
نویسندگان
چکیده
منابع مشابه
Helix-Coil Stabilities of L-Alanine and L-Leucine in Mixed Organic Solvents
For several years, we have been engaged in evaluating the helix-coil stability constants for the naturally occurring amino acids in water.’ Specifically, we have determined the values of the parameters u and s of the Zimm-Bragg theory2 for several amino acids in aqueous solution, using the “host-guest” t e~hn ique .~ A similar series of studies to determine these same parameters in nonaqueous s...
متن کاملPrediction of the thermodynamics of protein unfolding: the helix-coil transition of poly(L-alanine).
The method given earlier for predicting the thermodynamics of protein unfolding from the x-ray structure of a protein is applied here to the poly(L-alanine) helix. First, the fitting parameters derived earlier from a data base of 10 proteins were used to predict the unfolding thermodynamics of 4 other proteins. The agreement between the observed and predicted values is comparable to that found ...
متن کاملTriple Helix-Forming Oligonucleotide
Triple-helical DNA can be formed by oligonucleotides that bind as third strands of DNA in a sequencespecific manner in the major groove in homopurine/homopyrimidine stretches in duplex DNA. Such triple helix-forming oligonucleotides have been used to inhibit gene expression by blocking transcription factor access to promoter sites in transient expression assays. In an alternative approach to ge...
متن کاملNetworks of helix-forming polymers.
Biological molecules can form hydrogen bonds between nearby residues, leading to helical secondary structures. The associated reduction of configurational entropy leads to a temperature dependence of this effect: the helix-coil transition. Since the formation of helices implies a dramatic shortening of the polymer dimensions, an externally imposed end-to-end distance R affects the equilibrium h...
متن کاملApparent helix-coil transition for poly (L-alanine) as measured by nuclear magnetic resonance.
The previous contention by several groups that double peaks that arise in NMR spectra from NH and alpha-CH protons of poly L-alanines are caused by the coexistence of helical and random-coil structures in solution is disputed.
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1992
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.89.16.7821